In the back division, Tom Williams starts at full back ahead of Gavin Duffy, who drops to the bench. The 21 year-old will be making his first start in the team this season.

In the pack, Mike Worsley comes into the front row to replace Maurice Fitz Gerald, who suffered a hamstring injury last weekend. Worsley will start at loose head, with Ceri Jones moving over to the tight head and Mark Lambert coming onto the bench as cover for the two prop forwards.

A calf strain injury once again rules out Ugo Monye.

"One look at the scoreline from Castres game against the previously undefeated Neath-Swansea Ospreys last Saturday gives you a clear indication of the task we face this weekend," said Mark Evans, NEC Harlequins Chief Executive. "They are a very experienced side with a strong pack of forwards and we are expecting an incredibly physical contest."

"We have played well in our last three matches and on another day would have come away with victories against both Leicester Tigers and Munster. However, as good as the performances have been in recent weeks the fact remains that we are still looking for our first win of the season and a victory over Castres is essential if we are to have any serious ambition of progressing in the tournament."

The full team is as follows:

15. Tom Williams
14. George Harder
13. Will Greenwood
12. Dafydd James
11. Simon Keogh
10. Jeremy Staunton
9. Steve So'oialo
1. Mike Worsley
2. Tani Fuga
3. Ceri Jones
4. Roy Winters
5. Simon Miall
6. Nick Easter
7. Andre Vos (Capt.)
8. Tony Diprose

Replacements:
16. Ace Tiatia
17. Mark Lambert
18. Opeta Palepoi
19. Luke Sherriff
20. Andy Dunne
21. Mel Deane
22. Gavin Duffy