In the back division, Ugo Monye misses out due to a calf strain and his place on the left wing is taken by Simon Keogh.

In the pack, Maurice Fitz Gerald has recovered from the head injury that forced him to withdraw from the game last week and makes his first start for Quins in the Premiership at tight head prop. He replaces Mark Lambert, who drops to the bench.

Ace Tiatia is amongst the replacements after missing out against Gloucester due to a back injury, while both Matt Henjak and Nick Easter are set to make their Premiership debuts for Quins at the Stoop.

"The two sides have experienced completely contrasting starts to the season with the Tigers riding high and ourselves getting off to the worst possible start," said Mark Evans, NEC Harlequins Chief Executive. "Six defeats in as many games constitutes a dreadful return, but it is now vital that we exhibit strong desire and mental toughness as we work to break out of a slump."

"Playing the team generally acknowledged to be the best in the country is an ideal opportunity to build upon a much more spirited performance against Gloucester last weekend, which saw us play well with the ball in hand but let ourselves down in defence."

"Tomorrow will be a great challenge for us but it is one we have risen to in the recent past and I'm sure it will be a great match in front of a sell out crowd at the Stoop."

The full team is as follows:

15. Gavin Duffy
14. George Harder
13. Will Greenwood
12. Dafydd James
11. Simon Keogh
10. Jeremy Staunton
9. Matt Henjak
1. Ceri Jones
2. Tani Fuga
3. Maurice Fitz Gerald
4. Roy Winters
5. Simon Miall
6. Nick Easter
7. Andre Vos (Capt.)
8. Tony Diprose

Replacements:
16. Ace Tiatia
17. Mark Lambert
18. Karl Rudzki
19. Luke Sherriff
20. Steve So'oialo
21. Adrian Jarvis
22. Andy Reay