In the back division, David Strettle has recovered from the broken toe he sustained training with the England squad back in August and will start his first game of the season on the wing in place of Simon Keogh. Also returning from injury is Danny Care, who starts at scrum half and replaces the injured Steve So'oialo, while Tosh Masson is preferred to Jordan Turner-Hall in the midfield.

In the pack, John Brooks starts his first Premiership game for Quins at tighthead prop, with Mike Ross dropping to the bench, while Nicolas Spanghero comes in for Ollie Kohn and starts in the second row alongside Jim Evans.

In the back row, Will Skinner and Chris Hala'Ufia replace Paul Volley and Tom Guest respectively. In Volley's absence, Chris Malone will captain the side.

On the bench, summer signing James Percival features in the squad for the first time this season, as does Adrian Jarvis who is back from injury.

The full team is as follows:

15. Mike Brown
14. David Strettle
13. Hal Luscombe
12. Tosh Masson
11. Ugo Monye
10. Chris Malone (Capt.)
9. Danny Care
1. Ceri Jones
2. Tani Fuga
3. John Brooks
4. Nicolas Spanghero
5. Jim Evans
6. Chris Robshaw
7. Will Skinner
8. Chris Hala'Ufia

Replacements:
16. Chris Brooker
17. Mike Ross
18. James Percival
19. Tom Guest
20. Simon Keogh
21. Adrian Jarvis
22. Jordan Turner-Hall