Danny Care will start in the number 9 shirt against Wales in Saturday's Investec International at Twickenham Stadium (2.30pm).
The Leicester Tigers centre Manusamoa Tuilagi will make his England debut against Wales on Saturday, starting at outside centre, as England continue their Rugby World Cup build-up in the first leg of a home and away double header against the Welsh.
"I'm really proud to be winning my first cap," said the 20-year-old Aviva Premiership Young Player of the Year, who impressed for England Saxons last season. "There is a lot of competition for places and I just want to take this chance and do the best I can for the team. The boys have worked hard during the camp but now we have to perform against Wales. "
Tuilagi will partner London Wasps' Riki Flutey, while flyhalf Jonny Wilkinson will win his 86th cap and Delon Armitage also gets a start at fullback.
Lewis Moody captains the side in a pack that also sees Matt Stevens start an international for the first time since November 2008, while there are bench call-ups for the uncapped Saracens lock Mouritz Botha and Gloucester wing Charlie Sharples.
15 Delon Armitage (London Irish)
14 Matt Banahan (Bath Rugby)
13 Manusamoa Tuilagi (Leicester Tigers)
12 Riki Flutey (London Wasps)
11 Mark Cueto (Sale Sharks)
10 Jonny Wilkinson (Toulon) 9 Danny Care (Harlequins)
1 Alex Corbisiero (London Irish)
2 Dylan Hartley (Northampton Saints)
3 Matt Stevens (Saracens)
4 Simon Shaw (Unattached)
5 Tom Palmer (Stade Francais)
6 Tom Croft (Leicester Tigers)
7 Lewis Moody (capt, Bath Rugby)
8 James Haskell (Ricoh Black Rams) Replacements
16 Lee Mears (Bath Rugby)
17 Dave Wilson (Bath Rugby)
18 Mouritz Botha (Saracens)
19 Tom Wood (Northampton Saints)
20 Richard Wigglesworth (Saracens)
21 Charlie Hodgson (Saracens)
22 Charlie Sharples (Gloucester Rugby)
Harlequins fan Ed Atkin won the Etihad Airways 'Up and Under' competition at the Northampton Saints game. As a result, he and a friend have won a holiday to Abu Dhabi courtesy of Etihad Airways and the Abu Dhabi Tourism & Culture Authority.