Harlequins head back into Heineken Cup mode off the back of two Premiership victories taking their undefeated form to 14 from 14.
The Quins team sees a number of players returning, having missed the victory over London Wasps last weekend.
George Robson returns to the front five alongside Tomas Vallejos, with the hooker rotation between Chris Brooker and Joe Gray continuing. Brooker will take over in the starting line up in between Joe Marler and James Johnston. Nick Easter returns at number 8, allowing Captain, Chris Robshaw to return to the flank partnered with Maurie Fa'asavalu.
The backline remains unchanged from Wasps, other than Benjamin Urdapilleta taking over at inside centre from Tom Casson who has picked up an ankle injury in training.
Alongside Joe Gray, Mark Lambert and Kyle Sinckler cover the front row. Charlie Matthews and Luke Wallace who started and played so well in the Wasps game will cover the back five of the scrum. Richard Bolt and Rory Clegg cover the specialist roles at 9 and 10, with Ugo Monye covering the remainder of the back line.
Harlequins team to face Toulouse:
15. Mike Brown
14. Seb Stegmann
13. Matt Hopper
12. Benjamin Urdapilleta
11. Sam Smith
10. Nick Evans
9. Danny Care
1. Joe Marler
2. Chris Brooker
3. James Johnston
4. Tomas Vallejos
5. George Robson
6. Maurie Fa'asavalu
7. Chris Robshaw (C)
8. Nick Easter
16. Joe Gray
17. Mark Lambert
18. Kyle Sinckler
19. Charlie Matthews
20. Luke Wallace
21. Richard Bolt
22. Rory Clegg
23. Ugo Monye