Mike Brown starts at full back, with Tom Williams and Sam Smith partnering in the back three. Ugo Monye is undergoing further treatment following his injury against Leicester and will be reassessed early next week. Jordan Turner-Hall and George Lowe start in the centres, with Danny Care and Nick Evans at half back.

Joe Gray returns at hooker to make his 50^th appearance for Harlequins. Gray is the only change from the forward pack that faced Leicester Tigers. Joe Marler and James Johnston start at prop as Olly Kohn and George Robson partner in the second row. Captain Chris Robshaw starts to make his 100^th Premiership appearance, with Maurie Fa'asavalu and Nick Easter completing the back row.

Rob Buchanan, Mark Lambert and Will Collier will look to impact in the front row, with Tomas Vallejos and Tom Guest ready to cover in the back five. Karl Dickson and Rory Clegg provide specialist half back cover and Matt Hopper offers cover for the remainder of the backline.

Harlequins team to face Sale Sharks

15. Mike Brown
14. Tom Williams
13. George Lowe
12. Jordan Turner-Hall
11. Sam Smith
10. Nick Evans
9. Danny Care

1. Joe Marler
2. Joe Gray
3. James Johnston
4. Olly Kohn
5. George Robson
6. Maurie Fa'asavalu
7. Chris Robshaw (C)
8. Nick Easter

16. Rob Buchanan
17. Mark Lambert
18. Will Collier
19. Tomas Vallejos
20. Tom Guest
21. Karl Dickson
22. Rory Clegg
23. Matt Hopper