Stuart Lancaster has today named five Harlequins players in the squad that will face Fiji in the opening Test of the QBE internationals on Saturday.
Ugo Monye will earn his first cap since March 2010 on the wing while Danny Care, who played in the third test in South Africa over the summer, starts at scrum-half.
Joe Marler is named at loose head while Chris Robshaw captains in the back-row. Mike Brown will cover Alex Goode from the bench.
England Head Coach Stuart Lancaster said: "This QBE International series will be a real marker of where we are as a squad. We are playing four back to back matches in four weeks against the top teams in the world and we are confident we can rise to the challenge. The foundations are in place, now it's time for us to execute and deliver."
England (v Fiji, 2.30pm Saturday, Twickenham Stadium)
15. Alex Goode (Saracens, 2 caps)
14. Charlie Sharples (Gloucester Rugby, 2 caps)
13. Manusamoa Tuilagi (Leicester Tigers, 13 caps)
12. Brad Barritt (Saracens, 7 caps)
11. Ugo Monye (Harlequins, 13 caps)
10. Toby Flood (Leicester Tigers, 50 caps)
9. Danny Care (Harlequins, 33 caps)
1. Joe Marler (Harlequins, 3 caps)
2. Tom Youngs (Leicester Tigers, 0 caps)
3. Dan Cole (Leicester Tigers, 31 caps)
4. Tom Palmer (London Wasps, 40 caps)
5. Geoff Parling (Leicester Tigers, 8 caps)
6. Tom Johnson (Exeter Chiefs, 3 caps)
7. Chris Robshaw (Harlequins, capt, 8 caps)
8. Thomas Waldrom (Leicester Tigers, 2 caps)
Replacements
16. David Paice (London Irish, 2 caps)
17. David Wilson (Bath Rugby, 19 caps)
18. Mako Vunipola (Saracens, 0 caps)
19. Joe Launchbury (London Wasps, 0 caps)
20. Tom Wood (Northampton Saints, 9 caps)
21. Ben Youngs (Leicester Tigers, 24 caps)
22. Owen Farrell (Saracens, 8 caps)
23. Mike Brown (Harlequins, 7 caps)