Harlequins return to the Aviva Premiership on Sunday following two wins in the Heineken Cup to face London Irish at the Madejski Stadium, kick off 2.15pm.
There are three changes to the side which defeated Connacht in Galway last week. In the backs, Ugo Monye returns from injury to start on the wing, while Tom Casson will make his first senior appearance of the season, replacing Jordan Turner-Hall in the centres.
Turner-Hall had 120mls of blood drained from his knee prior to playing Connacht last week and has been given this weekend off. The centre will join the England squad on Sunday evening and will be fit to train fully next week.
Ben Botica continues at fly-half with Nick Evans expected to return next week.
In the forwards, Tom Guest swaps with Maurie Fa'asavalu to start alongside captain, Chris Robshaw and Nick Easter in the back row.
Harlequins team
15. Mike Brown
14. Tom Williams
13. Matt Hopper
12. Tom Casson
11. Ugo Monye
10. Ben Botica
9. Danny Care
1. Joe Marler
2. Rob Buchanan
3. James Johnston
4. Olly Kohn
5. George Robson
6. Tom Guest
7. Chris Robshaw (C)
8. Nick Easter
Replacements
16. Dave Ward
17. Mark Lambert
18. Will Collier
19. Charlie Matthews
20. Maurie Fa'asavalu
21. Karl Dickson
22. Rory Clegg
23. Seb Stegmann
Harlequins play London Irish in the Big Game 5 on December the 29
th, for tickets and information please visit
www.thebiggame.co.uk