The Londoners will be looking for a performance to top the seeding from the group stages and secure a home semi-final in the competition.

Fly-half Rory Clegg, who is currently on loan/ dual registration with Leeds Carnegie, returns for this fixture after playing a key role for the RFU Championship side against Jersey, Leinster 'A' and Bristol.

With Tom Casson picking up a minor knock in last week's victory over London Welsh, Ben Botica moves to inside centre.

Ross Chisholm starts at full-back having made his comeback from injury last week. Chisholm's injury was sustained in the Aviva Premiership victory over Leicester Tigers.

There are no changes to the forward pack, with "LV= Breakthrough Player of the Year" nominees Joe Trayfoot and captain Luke Wallace combining with Tom Guest in the back row.

Among the replacements, James Johnston and Maurie Fa'asavalu are named in the absence of Kyle Sinckler and Jack Clifford to the England U20s.

Harlequins Team
15. Ross Chisholm
14. Seb Stegmann
13. Matt Hopper
12. Ben Botica
11. Sam Smith
10. Rory Clegg
9. Karl Dickson

1. Mark Lambert
2. Dave Ward
3. Will Collier
4. Sam Twomey
5. Charlie Matthews
6. Joe Trayfoot
7. Luke Wallace (C)
8. Tom Guest

16. Harry Allen
17. Darryl Marfo
18. James Johnston
19. Charlie Walker
20. Maurie Fa'asavalu
21. Jordan Burns
22. Louis Grimoldby
23. Ollie Lindsay-Hague